相似性分析用于丹参二萜醌组分平衡溶解度和油水分配系数的研究(3)
Investigation on equilibrium solubility and apparent oil/water partition
coefficient of diterpenoid tanshinone component by similarity analysis methods
YU Dan-hong1，2， JIA Xiao-bin1，2*
(1. Key Laboratory of New Drug Delivery System of Chinese Materia Medica， Jiangsu Provincial Academy of
Chinese Medicine， Nanjing 210028， China；2.Nanjing University of Chinese Medicine， Nanjing 210046， China)
[Abstract] Objective： To study the equilibrium solubility and apparent oil/water partition coefficient of diterpenoid tanshinone component by similarity analysis methods， so as to lay the foundation for Salvia diterpenoid quinone component of the overall solubility characterization. Method： Taking Salvia diterpenoid quinone component as model drug， determined the equilibrium solubility and partition coefficients of the components in different buffer， evaluated the degree of similarity of each component based on the cosine and Grubbs. Result： The representative composition of Salvia diterpenoid quinone component， namely dihydrotanshinone Ⅰ， tanshinone Ⅰ， cryptotanshinone and tanshinone ⅡA had similar properties of equilibrium solubility and partition coefficients in different pH buffer. This similarity was not only manifested in the trends， but also reflected the value. Conclusion： This similarity assessment reflected the degree of deviation and dispersion of components， which was applicable to the study of the components； the similarity assessment could increase the science and rationality of component evaluation， and at the same time could optimize the structure of the component.
[Key words] component of traditional Chinese medicine； similarity analysis； cosine； Grubbs； diterpenoid tanshinone； equilibrium solubility； apparent oil/water partition coefficient
doi：10.4268/cjcmm20131204, 百拇医药(郁丹红 贾晓斌)
coefficient of diterpenoid tanshinone component by similarity analysis methods
YU Dan-hong1，2， JIA Xiao-bin1，2*
(1. Key Laboratory of New Drug Delivery System of Chinese Materia Medica， Jiangsu Provincial Academy of
Chinese Medicine， Nanjing 210028， China；2.Nanjing University of Chinese Medicine， Nanjing 210046， China)
[Abstract] Objective： To study the equilibrium solubility and apparent oil/water partition coefficient of diterpenoid tanshinone component by similarity analysis methods， so as to lay the foundation for Salvia diterpenoid quinone component of the overall solubility characterization. Method： Taking Salvia diterpenoid quinone component as model drug， determined the equilibrium solubility and partition coefficients of the components in different buffer， evaluated the degree of similarity of each component based on the cosine and Grubbs. Result： The representative composition of Salvia diterpenoid quinone component， namely dihydrotanshinone Ⅰ， tanshinone Ⅰ， cryptotanshinone and tanshinone ⅡA had similar properties of equilibrium solubility and partition coefficients in different pH buffer. This similarity was not only manifested in the trends， but also reflected the value. Conclusion： This similarity assessment reflected the degree of deviation and dispersion of components， which was applicable to the study of the components； the similarity assessment could increase the science and rationality of component evaluation， and at the same time could optimize the structure of the component.
[Key words] component of traditional Chinese medicine； similarity analysis； cosine； Grubbs； diterpenoid tanshinone； equilibrium solubility； apparent oil/water partition coefficient
doi：10.4268/cjcmm20131204, 百拇医药(郁丹红 贾晓斌)