[摘要]目的：探讨宫颈癌组织中hMSH2、p53及PTEN蛋白表达的关系及意义。方法：采用免疫组织化学SP法检测54例宫颈癌中的hMSH2、p53及PTEN蛋白表达。结果：①宫颈癌组织中，hMSH2、p53蛋白阳性表达率分别为62.96%、66.67%，PTEN蛋白缺失表达率55.56%。②在hMSH2阳性表达的宫颈癌患者中，p53蛋白阳性表达率为76.47%、PTEN蛋白缺失表达率为52.94%。hMSH2与p53表达呈正相关(P<0.05)。 结论：宫颈癌组织中，p53基因突变与错配修复基因的功能缺陷有关。

    [关键词] 宫颈癌；hMSH2；P53；PTEN；免疫组织化学

    [中图分类号] R737.3 [文献标识码]A [文章编号]1674-4721(2009)05(a)-014-02

    Expressions of hMSH2、p53 and PTEN in cervical cancers and its significance

    SU Hong1，LI Mei2, WANG Xiuying3, LV Shen2*

    (1.Department of Gynaecology and Obstetrics, the Second Affiliated Hospital, Dalian Medical University, Dalian116027, China； 2. Central Laboratory, the Second Affiliated Hospital of Dalian Medical University, Dalian116027, China；3. Department of Gynaecology and Obstetrics, Dalian Maternity Hospital ......