氟伏沙明联合丁螺环酮治疗强迫障碍的效果观察(1)
[摘要] 目的 探讨氟伏沙明联合丁螺环酮治疗强迫障碍的临床效果。 方法 选取2012年3月～2014年3月来本院就诊的门诊和住院患者50例，将其随机分为研究组和对照组，每组25例，研究组服用氟伏沙明和丁螺环酮治疗，对照组单用氟伏沙明治疗，疗程为8周。治疗前及治疗后2、4、6、8周采用耶鲁-布朗强迫症状量表(Y-BOCS)、汉密顿焦虑量表(HAMA)进行评定，同时采用副反应量表(TESS)评定不良反应。 结果 两组总有效率差异无统计学意义(P>0.05)。两组在治疗2、4、6、8周后Y-BOCS、HAMA评分均下降，4、6、8周末与治疗前比较，差异有统计学意义(P<0.05)，研究组在治疗后6、8周末的评分与对照组比较，差异有统计学意义(P<0.05)。两组不良反应发生率差异无统计学意义(P>0.05)。 结论 氟伏沙明联合丁螺环酮治疗强迫障碍是安全有效的。
[关键词] 强迫障碍；氟伏沙明；丁螺环酮
[中图分类号] R971 [文献标识码] A [文章编号] 1674-4721(2015)02(b)-0122-03
The effect observation of fluvoxamine combined with buspirone in treatment of obsessive-compulsive disorder
CHEN Hai-feng CAO Bo LI Duo-cong CHEN Hai-bo
Department of Psychiatric，the Third People′s Hospital of Jian City in Jiangxi Province，Jian 343000，China
[Abstract] Objective To explore the clinical efficacy of fluvoxamine combined with buspirone in treatment of obsessive-compulsive disorder. Methods 50 patients with obsessive-compulsive disorder treated in our hospital from March 2012 to March 2014 were selected，and were randomly divided into research group (n=25) and control group (n=25).Fluvoxamine and buspirone was given to the research group，while only fluvoxamine was given to the control group，the treatment course were 8 weeks.Yale-Brown obsessive compulsive sale (Y-BOCS)，Hamilton anxiety scale (HAMA) before and after treatment for 2、4、6、8 weeks was assessed，treatment emergent symptoms scale (TESS) was used to assess the side effects. Results There was no significant difference about the total effective rate between the two groups (P>0.05).Y-BOCS，HAMA scores of both groups were decreased after treatment，scores had significant difference after 4，6，8 weeks treatment (P<0.05)，while after 6，8 weeks treatment scores between the two groups had significant difference (P<0.05).The incidence rate of side effects between the two groups had no significant difference (P>0.05). Conclusion Fluvoxamine combined with buspirone is safe and effective in treatment of obsessive-compulsive disorder.
[Key words] Obsessive-compulsive disorder；Fluvoxamine；Buspirone
强迫障碍是一种以强迫思维和强迫行为为主要临床表现的精神障碍，多发病于青春期，患者常感到焦虑和痛苦，但又无法摆脱，病程迁延的患者还会出现服药依从性差，治疗效果不理想，造成患者社会功能严重受损，生活质量下降，给患者及其家庭造成严重的经济和精神负担，被世界卫生组织列为十大致残疾病之一，高致残率导致预后差[1-2]，同时也给社会带来一些不稳定因素。强迫障碍的诊治和治疗结局的改善越来越成为精神科医生关注的一个重要问题，而强迫障碍治疗首要的目标是让患者能够控制自己的强迫症状[3]。本文主要研究氟伏沙明联合丁螺环酮治疗强迫障碍的效果和安全性。
1 资料与方法
1.1 一般资料
选取2012年3月～2014年3月来本院就诊的门诊和住院患者50例，均符合ICD-10强迫障碍的诊断标准，耶鲁-布朗强迫症状量表(Y-BOCS)评分≥16分。排除药物及酒精依赖史，无心、肝、肾青光眼等严重躯体疾病，无妊娠及哺乳妇女。将50例患者随机分为研究组和对照组，每组25例。研究组：男11例，女14例，年龄16～50岁，平均(25.0±10.5)岁，病程2～24个月，平均(8.0±3.5)个月；对照组：男13例，女12例，年龄17～52岁，平均(24.0±11.4)岁，病程3～23个月，平均(9.0±3.8)个月；两组患者的性别、年龄、病程等资料比较，差异无统计学意义(P>0.05)，具有可比性。 (陈海峰等)
[关键词] 强迫障碍；氟伏沙明；丁螺环酮
[中图分类号] R971 [文献标识码] A [文章编号] 1674-4721(2015)02(b)-0122-03
The effect observation of fluvoxamine combined with buspirone in treatment of obsessive-compulsive disorder
CHEN Hai-feng CAO Bo LI Duo-cong CHEN Hai-bo
Department of Psychiatric，the Third People′s Hospital of Jian City in Jiangxi Province，Jian 343000，China
[Abstract] Objective To explore the clinical efficacy of fluvoxamine combined with buspirone in treatment of obsessive-compulsive disorder. Methods 50 patients with obsessive-compulsive disorder treated in our hospital from March 2012 to March 2014 were selected，and were randomly divided into research group (n=25) and control group (n=25).Fluvoxamine and buspirone was given to the research group，while only fluvoxamine was given to the control group，the treatment course were 8 weeks.Yale-Brown obsessive compulsive sale (Y-BOCS)，Hamilton anxiety scale (HAMA) before and after treatment for 2、4、6、8 weeks was assessed，treatment emergent symptoms scale (TESS) was used to assess the side effects. Results There was no significant difference about the total effective rate between the two groups (P>0.05).Y-BOCS，HAMA scores of both groups were decreased after treatment，scores had significant difference after 4，6，8 weeks treatment (P<0.05)，while after 6，8 weeks treatment scores between the two groups had significant difference (P<0.05).The incidence rate of side effects between the two groups had no significant difference (P>0.05). Conclusion Fluvoxamine combined with buspirone is safe and effective in treatment of obsessive-compulsive disorder.
[Key words] Obsessive-compulsive disorder；Fluvoxamine；Buspirone
强迫障碍是一种以强迫思维和强迫行为为主要临床表现的精神障碍，多发病于青春期，患者常感到焦虑和痛苦，但又无法摆脱，病程迁延的患者还会出现服药依从性差，治疗效果不理想，造成患者社会功能严重受损，生活质量下降，给患者及其家庭造成严重的经济和精神负担，被世界卫生组织列为十大致残疾病之一，高致残率导致预后差[1-2]，同时也给社会带来一些不稳定因素。强迫障碍的诊治和治疗结局的改善越来越成为精神科医生关注的一个重要问题，而强迫障碍治疗首要的目标是让患者能够控制自己的强迫症状[3]。本文主要研究氟伏沙明联合丁螺环酮治疗强迫障碍的效果和安全性。
1 资料与方法
1.1 一般资料
选取2012年3月～2014年3月来本院就诊的门诊和住院患者50例，均符合ICD-10强迫障碍的诊断标准，耶鲁-布朗强迫症状量表(Y-BOCS)评分≥16分。排除药物及酒精依赖史，无心、肝、肾青光眼等严重躯体疾病，无妊娠及哺乳妇女。将50例患者随机分为研究组和对照组，每组25例。研究组：男11例，女14例，年龄16～50岁，平均(25.0±10.5)岁，病程2～24个月，平均(8.0±3.5)个月；对照组：男13例，女12例，年龄17～52岁，平均(24.0±11.4)岁，病程3～23个月，平均(9.0±3.8)个月；两组患者的性别、年龄、病程等资料比较，差异无统计学意义(P>0.05)，具有可比性。 (陈海峰等)