动态增强磁共振成像与直肠癌分化程度的关系(1)
[摘要]目的 探讨动态增强磁共振成像(DCE-MRI)与直肠癌分化程度的关系。方法 选取2017年1月～2018年5月我院行DCE-MRI检查的56例患者的资料，其中28例经病理学确诊为直肠癌的患者作为观察组，28例非直肠癌患者作为对照组，比较两组的各项参数，分析参数结果与术后病理分化程度的关系。结果 观察组DCE-MRI各参数结果均高于对照组，差异有统计学意义(P<0.05)；28例直肠癌患者中，不同分化组间定量参数转运常数(Ktrans)、速率常数(Kep)及增强曲线下的初始面积(iAUC)比较，差异有统计学意义(P<0.05)；不同分化组间血管外细胞外间隙体积百分比(Ve)比较，差异无统计学意义(P>0.05)。结论 DCE-MRI可对直肠癌微循环差异进行反映，参数指标与分化程度具有一定的关系，可为术前评估提供依据。
[关键词]动态增强磁共振成像；直肠癌；分化
[中图分类号] R587.2 [文献标识码] A [文章编号] 1674-4721(2019)4(a)-0163-03
[Abstract] Objective To investigate the relationship between dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) and the degree of rectal cancer differentiation. Methods From January 2017 to May 2018， 56 cases data of patients with DCE-MRI were selected. Among them， 28 patients with rectal cancer were diagnosed by pathology as observation group， and 28 patients with non-rectal cancer as control group. The parameters were compared and the relationship between the parameters and the degree of pathological differentiation after operation was analyzed. Results The results of DCE-MRI parameters in the observation group were higher than those in the control group， and the difference was statistically significant (P<0.05). Among 28 patients with rectal cancer， there were significant differences in quantitative parameter transport constant (Ktrans)， rate constant (Kep) and initial area (iAUC) under enhancement curve between different differentiation groups (P<0.05). There was no significant difference in extracellular space volume percentage (Ve) between the two groups (P>0.05). Conclusion Dynamic contrast-enhanced magnetic resonance imaging can respond to microcirculation differences of rectal cancer， and the parameters are correlated with the degree of differentiation， which can provide a basis for preoperative evaluation.
[Key words] Dynamic contrast enhanced magnetic resonance imaging； Rectal cancer； Differentiation
直肠癌是消化道最常见的恶性肿瘤，早期无明显症状，随疾病发展，可出现排便习惯改变、血便、会阴部疼痛等症状，对患者身心健康造成严重影响[1]。临床治疗以手术治疗为主，术前行有效检查，可为治疗方式的选择提供数据支持。动态增强磁共振成像(DCE-MRI)可直接作出体层图像，无伪影，且无需注射造影剂，不会对机体造成不良影响[2]。本研究选取我院行动态增强磁共振成像检查的56例患者的资料进行分析，旨在探讨DCE-MRI与直肠癌分化程度的关系，现报道如下。
1资料与方法
1.1一般方法
选取2017年1月～2018年5月我院行DCE-MRI检查的56例患者的资料，其中28例经病理学确诊为直肠癌的患者作为观察组，28例非直肠癌患者作为对照组。纳入标准：无精神疾病史及认知功能障碍者；无合并其他严重脏器疾病者。排除标准：妊娠期疾哺乳期女性；不愿参与者。观察组中，男18例，女10例；年龄55～68岁，平均(61.25±0.31)岁；对照组中，男15例，女13例；年龄50～68岁，平均(61.11±0.87)岁。兩组患者的一般资料比较，差异无统计学意义(P>0.05)，具有可比性。本研究经我院医学伦理委员会批准。
1.2方法
患者检查前行常规清洁灌肠，取仰卧位，采用核磁共振成像系统(Siemens，型号：GE3.0HDxt)进行扫描，线圈中线位于耻骨上缘，调整扫描序列与参数。采用GD-DTPA做为对比剂，使用高压注射器行肘静脉注射，注射速率为3 ml/s，采用20 ml生理盐水冲管。动态扫描在药物注射15 s、1、3、5 min进行，检查时间为30～40 min。, 百拇医药(刘锋)
[关键词]动态增强磁共振成像；直肠癌；分化
[中图分类号] R587.2 [文献标识码] A [文章编号] 1674-4721(2019)4(a)-0163-03
[Abstract] Objective To investigate the relationship between dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) and the degree of rectal cancer differentiation. Methods From January 2017 to May 2018， 56 cases data of patients with DCE-MRI were selected. Among them， 28 patients with rectal cancer were diagnosed by pathology as observation group， and 28 patients with non-rectal cancer as control group. The parameters were compared and the relationship between the parameters and the degree of pathological differentiation after operation was analyzed. Results The results of DCE-MRI parameters in the observation group were higher than those in the control group， and the difference was statistically significant (P<0.05). Among 28 patients with rectal cancer， there were significant differences in quantitative parameter transport constant (Ktrans)， rate constant (Kep) and initial area (iAUC) under enhancement curve between different differentiation groups (P<0.05). There was no significant difference in extracellular space volume percentage (Ve) between the two groups (P>0.05). Conclusion Dynamic contrast-enhanced magnetic resonance imaging can respond to microcirculation differences of rectal cancer， and the parameters are correlated with the degree of differentiation， which can provide a basis for preoperative evaluation.
[Key words] Dynamic contrast enhanced magnetic resonance imaging； Rectal cancer； Differentiation
直肠癌是消化道最常见的恶性肿瘤，早期无明显症状，随疾病发展，可出现排便习惯改变、血便、会阴部疼痛等症状，对患者身心健康造成严重影响[1]。临床治疗以手术治疗为主，术前行有效检查，可为治疗方式的选择提供数据支持。动态增强磁共振成像(DCE-MRI)可直接作出体层图像，无伪影，且无需注射造影剂，不会对机体造成不良影响[2]。本研究选取我院行动态增强磁共振成像检查的56例患者的资料进行分析，旨在探讨DCE-MRI与直肠癌分化程度的关系，现报道如下。
1资料与方法
1.1一般方法
选取2017年1月～2018年5月我院行DCE-MRI检查的56例患者的资料，其中28例经病理学确诊为直肠癌的患者作为观察组，28例非直肠癌患者作为对照组。纳入标准：无精神疾病史及认知功能障碍者；无合并其他严重脏器疾病者。排除标准：妊娠期疾哺乳期女性；不愿参与者。观察组中，男18例，女10例；年龄55～68岁，平均(61.25±0.31)岁；对照组中，男15例，女13例；年龄50～68岁，平均(61.11±0.87)岁。兩组患者的一般资料比较，差异无统计学意义(P>0.05)，具有可比性。本研究经我院医学伦理委员会批准。
1.2方法
患者检查前行常规清洁灌肠，取仰卧位，采用核磁共振成像系统(Siemens，型号：GE3.0HDxt)进行扫描，线圈中线位于耻骨上缘，调整扫描序列与参数。采用GD-DTPA做为对比剂，使用高压注射器行肘静脉注射，注射速率为3 ml/s，采用20 ml生理盐水冲管。动态扫描在药物注射15 s、1、3、5 min进行，检查时间为30～40 min。, 百拇医药(刘锋)