[摘要] ING4基因是肿瘤抑制因子家族的新成员，近来研究发现，ING基因在正常组织中表达丰富，但在多种恶性肿瘤组织，如乳腺癌、胶质瘤、肺癌等中表达明显下调，ING4可通过增强p53基因的活性、恢复细胞间接触抑制、抑制肿瘤血管生成、抑制HIF的活性而抑制肿瘤的生长，还能诱导细胞凋亡，增加肿瘤细胞对放化疗的敏感性，本研究对ING4基因与肿瘤研究的新进展进行综述。

    [关键词] ING4基因；抑癌机制；肿瘤

    [中图分类号] R730.5 [文献标识码] A [文章编号] 2095-0616(2011)13-42-03

    Advancement of study between ING4 gene and tumor

    PAN Xuan WANG Chaoxia

    [Abstract] ING4 is considered to be a novel candidate tumor suppressor gene.Recently，it has been reported that ING4 was significantly downregulated in several m alignancies such as breast tumor ......